Bioinspired hybrid nano-materials from self-assembling peptide-polymer, lipopeptide and polymer-cholic acid conjugates. Line of research Synthesis and characterization of bioinspired amphiphilic conjugates that selfassemble in water providing nanometric materials whose functions, size and morphology are optimized for applications in the field of drug delivery. These conjugates, obtained by combination of suitable synthetic and natural polymers, peptides, fatty acids and cholic acids, produce by bottom-up processes nanosystems with functional and structural properties that can be tuned to obtain materials responsive to pH, temperature and ionic strength. allegato strategico 2018 eng.pdf Staff Supervisor: Giancarlo MasciAnita ScipioniDepartment staff: Andrea D'AnnibalePatrizia GentiliLuciano GalantiniFrancesca Leonelli Publications Peptides with regularly alternating enantiomeric sequence: From ion channel models to bioinspired nanotechnological applicationsCurcumin loaded nanocarriers obtained by self-assembly of a linear d,l-octapeptide-poly(ethylene glycol) conjugateSupramolecular assembly of a thermoresponsive steroidal surfactant with an oppositely charged thermoresponsive block copolymerSelf-assembly and drug release study of linear l,d-oligopeptide-poly(ethylene glycol) conjugatesPEGylated β‐Sheet Breaker Peptides as Inhibitors of β‐Amyloid FibrillizationBioinspired Nanotubes from Self‐Assembly of a Linear l,d‐Oligopeptide‐Poly(ethylene glycol) ConjugatePolymorphic Self-Organization of Lauroyl Peptide in Response to pH and ConcentrationSelf-Assembling Nanowires from a Linear L,D-Peptide Conjugated to the Dextran End GroupEffect of Temperature on the Association Behavior in Aqueous Mixtures of an Oppositely Charged Amphiphilic Block Copolymer and Bile Salt.Switchable Length Nanotubes from a Self-Assembling PH and Thermosensitive Linear L,D-Peptide-Polymer Conjugate Collaborations National collaborations: Diociaiuti Marco (Dip di Tecnologia e Salute, Istituto Superiore di Sanità, RM)Stefano Casciardi (Centro di Ricerche INAIL, Monteporzio Catone, RM)Giovanna Mancini (IMC-CNR)Cecilia Bombelli (IMC-CNR)Francesca Ceccacci (IMC-CNR)Francesca D’Acunzo (IMC-CNR)International collaborations: Luciani Paola (Institut für Pharmazie, Friedrich Schiller Universität, Jena, DE) Fundings and awards Fundings: Complexation and organization of Doxorubicin on anionic polymers - Progetto di ricerca (bando ricerca scientifica Sapienza 2022)A combined computational and experimental approach to investigate intelligent self-assembling bioinspired nano-materials - Progetto di ricerca (bando ricerca scientifica Sapienza 2021)Intelligent self assembling nano-systems for bio-medicine - Progetto di ricerca (bando ricerca scientifica Sapienza 2020)Intelligent self assembling nano-systems for bio-medicine - Progetto di ricerca (bando ricerca scientifica Sapienza 2019)Functional Hybrid nano-systems: from material sciences to nano-medicine - Progetto di ricerca (bando ricerca scientifica Sapienza 2018) Theme and ERC Theme: MaterialsERC: PE4_4 Surface science and nanostructuresPE5_7 Biomaterials synthesisPE5_14 Macromolecular chemistry Traineeship offer Area di ricerca: Physical chemistryIndustrial chemistryAvailability: three positionsCourse of study (advised): ChemistryIndustrial chemistry