Enantioselective synthesis of bioactive compounds Line of research This line of research deals with the synthesis of natural and non-natural bioactive molecules. Carrying out these studies allows not only to obtain compounds useful in the pharmaceutical or agrochemical fields but also constitutes the starting point for carrying out research in the field of asymmetric synthesis by developing strategies for solving the problems that the creation of complex chiral molecules necessarily entails. We are working on the synthesis of parthenolide and of malaymycin, two natural ompounds that possess interesting biological activity. Staff Supervisor: Francesca LeonelliDepartment staff: Luisa Maria MignecoFabrizio VeticaEnrico BodoLorenzo CelioLorenzo Michelini Publications Enantioselective Synthesis and X-ray Structure of (+)((4aS,5S,8aS)-5,8a-Dimethyl-7-methyleneoctahydro-2Hspiro[ naphthalene-1,2′-[1,3]dioxolan]-5-yl)methyl-4-iodobenzoateUnexpected Racemization in the Course of the Acetalization of (+)-(S)-5-Methyl-Wieland–Miescher Ketone with 1,2-Ethanediol and TsOH under Classical Experimental ConditionsN-Acetyl-l-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of AntiInflammatory 2-(N-Acetyl)-l-phenylalanylamido-2-deoxy-d-glucose (NAPA). Stereoselective Synthesis of Spiro-Decalin Oxindole Derivatives via Sequential Organocatalytic Michael–Domino Michael/Aldol Reaction Theme and ERC Theme: Life-Sciences chemistryERC: PE4_12 Chemical reactions: mechanisms, dynamics, kinetics and catalytic reactionsPE5_13 Homogeneous catalysisPE5_17 Organic chemistry Traineeship offer Area di ricerca: Organic chemistryCourse of study (advised): Chemistry
