Stereoselective syntheses of natural products and intermediates of dihydrobenzofuran structure and evaluation of their antitumor activity Line of research The research is oriented towards the synthesis and elaboration of 2,3-diaryloxiranes, even in enantioenriched form, to obtain polyfunctionalized 2,3-diaryl-2,3-dihydrobenzofurans stereoselectively . The goal is to develop an original and efficient synthesis of natural dimers of Resveratrol, as epsilon Viniferin, Gnetin C, delta Viniferin, possessing numerous biological and pharmacological activities, in particular anticancer one, together with testing the activity of novel dihydrobenzofuryl intermediates. Staff Supervisor: Paolo Lupattelli Publications Synthesis of new methoxy derivatives of trans 2,3-diaryl-2,3-dihydrobenzofurans and evaluation of their anti-inflammatory activityRegio- and Diastereoselective Organo-Zinc-Promoted Arylation of trans-2,3-Diaryloxiranes by Arylboronic Acids: Stereoselective Access to trans-2,3-Diphenyl-2,3-dihydrobenzofuranRegio- and Diastereo-Selective Biomimetic Synthesis of (±)-ε-Viniferin by NIS and ResveratrolRecent Advances in Synthetic Strategies to 2,3-Dihydrobenzofurans Theme and ERC Theme: Life-Sciences chemistryERC: LS1_1 Molecular interactionsPE5_17 Organic chemistryPE5_23 Organic chemistry Traineeship offer Area di ricerca: Organic chemistryAvailability: one positionCourse of study (advised): ChemistryIndustrial chemistry
